The present invention relates to a composition for increasing TRAIL sensitivity, which contains an inhibitor for inhibiting the expression or activity of the TIP41 protein. More particularly, it has been found that, when a hepatocellular carcinoma cell line which has TRAIL tolerance is treated with TIP41 siRNA and TRAIL, carcinoma-cell-specific apoptosis is induced, and apoptosis is induced not only in liver cancer but also in lung cancer and colorectal cancer which have TRAIL tolerance, and it has been found that, through animal experimentation, the size of a tumor is reduced and cancer cell apoptosis is induced, and the thus-induced apoptosis is caused by the activation of the MKK7/JNK delivery pathway due to the inhibition of TIP41 expression.； Therefore, the composition containing the inhibitor for inhibiting the expression or activity of the TIP41 protein according to the present invention can be valuably used in the prevention and treatment of cancer or as anticancer adjuvants.본 발명은 TIP41 단백질의 발현 또는 활성 억제제를 함유하는 TRAIL 감수성 증진용 조성물에 관한 것으로, 더욱 상세하게는 TRAIL 내성을 보이는 간암 세포주에 TIP41 siRNA와 TRAIL을 처리하였을 때, 암세포주 특이적 세포사멸이 유도되며, 간암뿐만 아니라, TRAIL 내성이 있는 폐암 및 대장암에서도 세포사멸을 유도하고, 동물실험을 통해 종양의 크기 감소 및 암세포의 사멸을 유도하며, 이러한 사멸이 TIP41 발현억제로 인한 MKK7/JNK 전달경로 활성에 기인됨을 밝혔으므로, TIP41 단백질 발현 또는 활성 억제제의 조성물을 암의 예방 및 치료용 또는 항암 보조제로 유용하게 사용될 수 있다.
