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Sonochemical Induction of ABCA1 Expression and Compositions Therefor
专利权人:
发明人:
Eric Coles,Michael Davidson
申请号:
US13826066
公开号:
US20140276363A1
申请日:
2013.03.14
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention provides compositions useful for transfecting cells (e.g., liver cells) to express ABCA1. The compositions described herein comprise a pharmaceutically acceptable aqueous carrier containing sonochemically-active microspheres together with a plasmid DNA construct encoding an active form of ABCA1 and at least one promoter for the expression thereof. Preferably, the sonochemically-active microspheres comprise, consist essentially of, or consist of gas bubbles (e.g., a fluorocarbon gas, such as octafluoropropane) encapsulated within protein-containing or lipid-containing shells (e.g., human serum albumin shells). The microspheres are disruptable by exposure to ultrasonic acoustic energy to release the encapsulated gas.
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