A pressure cuff inflation system, such as for treatment of deep vein thrombosis (DVT), comprises an airflow circuit for inflating one or more pressure cuffs using an air compressor 20 in communication with a pressurised air reservoir 24 arranged to accumulate air pressurised by the compressor 20 for rapid discharge into air pressure cuffs via a distributor 22A with solenoid valve-controlled 22 outlet ports 23. A controller 27 and a reservoir pressure switch 28 provides primary control of the reservoir air pressure and the controller and solenoid valve 25 provides secondary control of the release of pressurised air from the reservoir into the said distributor. The incorporation of an air reservoir enables fast pressure rise time in the cuffs whilst using only a small, quiet, low power compressor to maintain pressure in the reservoir.