Systems and methods for providing sensitive and specific alarms indicative of glycemic condition are provided herein. In an embodiment, a method of processing sensor data by a continuous analyte sensor includes: evaluating sensor data using a first function to determine whether a real time glucose value meets a first threshold； evaluating sensor data using a second function to determine whether a predicted glucose value meets a second threshold； activating a hypoglycemic indicator if either the first threshold is met or if the second threshold is predicted to be met； and providing an output based on the activated hypoglycemic indicator. The system (100) can include a continuous analyte sensor system (8), sensor electronics (12), a continuous analyte sensor (10), and other devices and/or sensors such as medicament delivery pump (2) and glucose meter (4) that can couple with one or more devices (14, 16, 18, and/or 20).
