Systems and methods for providing sensitive and specific alarms indicative of glycemic condition are provided herein. In an embodiment, a method of processing sensor data by a continuous analyte sensor includes: evaluating sensor data using a first function to determine whether a real time glucose value meets a first threshold； evaluating sensor data using a second function to determine whether a predicted glucose value meets a second threshold； activating a hypoglycemic indicator if either the first threshold is met or if the second threshold is predicted to be met； and providing an output based on the activated hypoglycemic indicator.
