Norman M. Kneteman,D. Lorne Tyrrell,David Frederick Mercer
申请号：
US13484073
公开号：
US08445745B2
申请日:
2012.05.30
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a urokinase-type plasminogen activator in the liver. The invention also features methods for identifying candidate therapeutic agents, e.g., agents having antiviral activity against HCV infection. The animals of the invention are also useful in assessing toxicity of various agents, as well as the activity of agents in decreasing blood lipids.
