A method for increasing susceptibility of microorganisms to antibiotics includes providing a microorganism； administering a single type of an antibiotic including a nitroimidazole compound to the microorganism； and administering any of an uronic, aldonic, ulosonic, and aldaric feedstock to the microorganism. The feedstock is adapted to promote cell metabolism and antibiotic activation, and inhibit antibiotic inactivation pathways in the microorganism causing increased sensitivity of the microorganism to the nitroimidazole.
