A safety device for a glove port includes a hatch that is rotatably fixable by a hinge arrangement to an outer frame of the glove port so as to rotate between a closing position and an opening position for preventing or allowing access to the glove port, respectively. The device further includes a sensor associated associable with the glove port and arranged for engaging and/or detecting an abutment portion of the hatch in the closing condition and generating an alarm signal when the abutment portion does not engage the sensor, in particular when the hatch is not in the closing position.