A closed-loop brain stimulation apparatus and a method for generating stimulation voltage thereof are provided. The closed-loop brain stimulation apparatus includes a brain signal receiving apparatus, a controller and a stimulation voltage generator. The brain signal receiving apparatus receives a plurality of brain signals. The controller operates phase correlation respectively operation on the brain signals during a plurality continuously time periods for obtaining a plurality of phase operation values, and generates a stimulation enable signal according to the phase operation values. The stimulation voltage generator generates a stimulation voltage according to the stimulation enable signal, and transports the stimulation voltage to an electrode pair.閉迴路腦電刺激裝置與其刺激電壓的產生方法。閉迴路腦電刺激裝置包括腦電波接收裝置、控制器以及刺激電壓產生器。腦電波接收裝置接收多數個腦電信號。控制器在連續的多個時間區間中分別針對腦電信號進行相位相關運算以獲得多數個相位運算值,並依據各相位運算值來產生刺激啟動信號。刺激電壓產生器依據刺激啟動信號以產生刺激電壓,並傳送刺激電壓至電極對。100‧‧‧閉迴路腦電刺激裝置110‧‧‧控制器120‧‧‧腦電波接收裝置130‧‧‧刺激電壓產生器PB‧‧‧探針EL‧‧‧電極對
