Zhengrong Zhou,Mark E. Meyerhoff,Melissa M. Reynolds
申请号：
US13093090
公开号：
US20120070483A1
申请日:
2011.04.25
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A polymeric coating is adapted to substantially eliminate thrombus formation when in contact with blood. The polymeric coating includes a first polymeric layer and a second polymeric layer. Interposed between the first and second polymeric layers is a polymeric matrix layer doped with at least one of a nitric oxide donor and a nitric oxide generator. The nitric oxide donor and/or the nitric oxide generator are capable of releasing or generating NO. A bioactive agent is either immobilized to the surface of the second polymeric layer or is incorporated into the polymeric matrix layer.
