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還元型生体分子の安定化剤及びその使用
专利权人:
UNIV OF TOKYO
发明人:
YATOMI YU,矢冨 裕,YASUKAWA KEIKO,安川 恵子
申请号:
JP2016200238
公开号:
JP2018063127A
申请日:
2016.10.11
申请国别(地区):
JP
年份:
2018
代理人:
摘要:
PROBLEM TO BE SOLVED: To provide a stabilizing agent for a reduced form biomolecule that prevents change of the reduced form biomolecule into an oxidized form biomolecule over time which begins immediately after sampling, a container containing the stabilizer, an analysis method using the stabilizing agent, and a reduced form albumin preparation.SOLUTION: The present invention provides a stabilizing agent for a reduced form biomolecule which contains an acid and its salt so that a final concentration of the acid and its salt is 20 mM or more after mixing them with the reduced form biomolecule, and the resulting mixture has a pH of 3.0 or more and not more than 7.5. The present invention also provides a reduced form albumin preparation, which has a pH of 3.0 or more and not more than 7.5, and contains the reduced form albumin at a concentration of 0.15 mM or more and not more than 16.00 mM, as well as the acid and its salt.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】還元型生体分子から酸化型生体分子への試料採取直後からの経時変化を防止するための還元型生体分子の安定化剤、前記安定化剤を含有する容器、前記安定化剤を用いた分析方法、及び還元型アルブミン製剤を提供する。【解決手段】本発明の還元型生体分子の安定化剤は、還元型生体分子と混合後の最終濃度が20mM以上となる酸及びその塩を含み、且つ、pH3.0以上pH7.5以下である。本発明の還元型アルブミン製剤は、pH3.0以上pH7.5以下であり、且つ、0.15mM以上16.00mM以下の還元型アルブミン、並びに酸及びその塩を含む。【選択図】なし
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