CARBAMATES DE PHÉNYLE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE L'ENZYME DE L'HYDROLASE DES AMIDES D'ACIDES GRAS ET MODULATEURS DU RÉCEPTEUR D3 DE LA DOPAMINE (D3DR)
Fondazione Istituto Italiano Di Tecnologia;The Regents of the University of California
发明人:
申请号：
EP14744009.3
公开号：
EP3022179B1
申请日:
2014.07.10
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The invention provides compounds of Formula (I) or pharmaceutically acceptable salts thereof wherein Ar&prime；, R1, R2, R3, R4, X, Y are as defined in the description of invention, as multi-target directed ligands (MTDLs) that are at the same time inhibitors of the fatty acid amide hydrolase (FAAH) enzyme and modulators of the D3 dopamine receptor (D3DR), their methods of preparation, formulations and therapeutic applications thereof.
