經改良的促凝血抗體农业专利-农业专业知识服务系统

发明人:: THORN, KARINA,索恩　凯瑞纳,索恩　凱瑞納,HANSEN, BJARNE GRAM,汉森　班杰瑞　格曼,漢森　班傑瑞　格曼,JOHNSEN, LAUST BRUUN,约翰森　罗斯特　布鲁恩,約翰森　羅斯特　布魯恩,HARNDAHL, MIKKEL NORS,汉尔恩达尔　奇尔　诺斯,漢爾恩達爾　奇爾　諾斯,YANG, ZHIRU,杨志茹,楊志茹,OESTERGAARD, HENRIK,欧

摘要：: The present invention relates to bispecifc procoagulant antibodies capable of binding to coagulation Factor IX (FIX) and/or the activated form thereof Factor IXa (FIXa), and Factor X (FX) and/or the activated form thereof Factor Xa (FXa) and promoting FX activation by FIXa, antibodies binding their epitopes or parts thereof and methods and composition for treating subjects suffering from a coagulopathy such as haemophilia A as well as kits, methods of manufacture and methods of use.本發明係關於能夠結合至凝血因子IX (FIX)及/或其活化型因子IXa (FIXa)與因子X (FX)及/或其活化型因子Xa (FXa)並促進透過FIXa的FX活化之雙特異性促凝血抗體、結合該等因子之表位或其部分表位的抗體、以及用於治療患有諸如血友病A之凝血病變之個體的方法與組成物及套組、製造方法與使用方法。