Samuelsson, Bengt Bertil,Classon, Bjorn Olof,Rosenquist, Asa Annica Kristina,Ayesa Alvarez, Susana,Wallberg, Hans Kristian,Jonsson, Carl Erik Daniel,Simmen, Kenneth Alan,Nilsson, Karl Magnus,De Kock,
申请号：
AU2006274862
公开号：
AU2006274862B2
申请日:
2006.07.28
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Inhibitors of HCV replication of formula (I) and the -oxides, salts,or stereoisomers thereof, wherein each dashed line represents an optional doublebond； X is N, CH and where X bears a double bond it is C； R is -OR,-NH-SOR； Ris hydrogen, and where X is C or CH,R may also be Calkyl； R is hydrogen, Calkyl,CalkoxyCalkyl, or Ccycloalkyl； nis 3, 4, 5, or 6； R and R taken together with the nitrogenatom to which they are attached form a bicyclic ring system selected from formula(II) wherein said ring system may optionally be substituted with 1-3 substituents；R is hydrogen； aryl； Het； Ccycloalkyl optionally substitutedwith Calkyl； or Calkyl optionally substituted withCcycloalkyl, aryl or with Het； Ris aryl； Het； Ccycloalkyloptionally substituted with Calkyl； or Calkyl optionallysubstituted with Ccycloalkyl, aryl or with Het； aryl is phenylor naphthyl, each of which may be optionally substituted with 1-3 substituents；Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturatedheterocyclic ring containing 1 to 4 heteroatoms each independently selectedfrom N, O or S, and being optionally substituted with 1-3 substituents pharmaceuticalcompositions containing compounds (I) and processes for preparing compounds(I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavirare also provided.
