[Formula 1] Stereoisomers N- oxides, and their salts and inhibitors of HCV replication of formula (I) [wherein the dotted line represents a double bond that may be present in each case has X N, and is CH and X It is C when carrying a double bondhalo, C 1-6 alkoxy, cyano hydrogen, C 3-7 cycloalkyl, aryl, Het, C 1-6 alkoxy, if R 1b and R 1a, R 1a and R 1b or is taken together with the nitrogen to which they are attached either C 1-6 alkyl optionally substituted with Het polyhaloC a C 1-6 alkoxy, C 3-7 cycloalkyl, aryl or Become a may be optionally substituted, to form a heterocyclic ring of 4 to 6 members L is a direct bond, -O -, - O-C 1-4 alkanediyl -, - O-CO -, - and - O-C or (= O) -NR 5a -O-C (= O) -NR 5a-C 1-4 alkanediyl X R 2 is hydrogen and is in C or CH In some cases, may be C 1-6 alkyl R 2 can also R 3 is hydrogen, C 1-6 alkyl, C 1-6 alkoxy C 1-6 alkyl, C 3-7 cycloalkyl, amino, - There mono di-C 1-6 alkylamino or saturated or aryl, R 4 is bicyclic heterocyclic 9-12 membered monocyclic or 5 or 6-membered fully unsaturated or partially unsaturated is a ring system, the ring system carbon ring members and wherein the remaining one nitrogen, and contains further heteroatoms 1 to 3 substituents selected from O, N and S, optionally wherein is an atom n is located in the 6 or 3,4,5 p is 1 or 2 respectively, aryl, 1, 2 or better when the ring system may optionally be substituted with where be a 1,2,3,4-tetrahydronaphthyl phenyl, naphthyl, or indanyl optionally substituted with 3 substituents Het is, Het and may be fused with a benzene ring and optionally is Good N, and contains 1 to 4 heteroatoms selected from S and O, saturated 5 or 6 membered, unsaturated or partially saturated and optionally substituted with one, two or three substituents optionally method for producing compound (I), as well as pharmaceutical compositions containing the compound (I) a heterocyclic ring fully unsaturated].【化1】式(I)のHCV複製のインヒビター及びそれらのN-オキシド、塩及び立体異性体[式中、点線はそれぞれ場合により存在しうる二重結合を表し;XはN、CH
