PROBLEM TO BE SOLVED: To provide a novel metalloprotein and a process for producing the same.SOLUTION: The novel metalloprotein is selenium-lactoferrin. In the process for producing the metalloprotein, the selenium-lactoferrin can be produced suitably by adding a selenium salt to a solution containing lactoferrin and/or apolactoferrin and then subjecting the resultant mixed solution to dialysis or ultrafiltration. The selenium-lactoferrin has an excellent therapeutic effect on corneal and conjunctival diseases, and is suitable for mass production on an industrial scale.