Holger Gruell,Anke De Vries,Sander Langereis,Johan Lub,Erica M. G. Aussems-Custers
申请号：
US13062742
公开号：
US09034298B2
申请日:
2009.09.08
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with 5 the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T 1/T 2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.
