GRUELL HOLGER,DE VRIES ANKE,LANGEREIS SANDER,LUB JOHAN,AUSSEMSCUSTERS Erica M G
申请号：
IN2204/CHENP/2011
公开号：
IN2011CN02204A
申请日:
2011.03.30
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with 5 the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T 1 /T 2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.
