WALCHECK, BRUCE KENNETH,KAUFMAN, DAN SAMUEL,WU, JIANMING,JING, YAWU,NI, ZHENYA
申请号：
CA2944199
公开号：
CA2944199A1
申请日:
2015.03.27
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
This disclosure describes, generally, a modified form of CD 16, genetically-modified cells that express the modified CD 16, and methods that involve the genetically-modified cells. The modified form of CD 16 can exhibit increased anti-tumor and/or anti- viral activity due, at least in part, to reduced susceptibility to ADAM17-mediated shedding upon NK cell stimulation.
