Bruce Kenneth Walcheck,Dan Samuel Kaufman,Jianming Wu,Yawu Jing,Zhenya Ni
申请号：
US16575624
公开号：
US20200017570A1
申请日:
2019.09.19
申请国别(地区):
US
年份:
2020
代理人:
摘要：
This disclosure describes, generally, a modified form of CD16, genetically-modified cells that express the modified CD16, and methods that involve the genetically-modified cells. The modified form of CD16 can exhibit increased anti-tumor and/or anti-viral activity due, at least in part, to reduced susceptibility to ADAM17-mediated shedding upon NK cell stimulation.
