ARAGON PHARMACEUTICALS, INC.;SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
发明人:
SMITH, Nicholas D.,HERBERT, Mark R.,OUERFELLI, Ouathek,DILHAS, Anna
申请号：
PE2019002096
公开号：
PE20200725A1
申请日:
2013.06.04
申请国别(地区):
PE
年份:
2020
代理人:
摘要：
The peak value of [3-fluoro-3-fluoropyridine-5-fluoro-3-pyridine-5-fluoro-3-pyridine-5-fluoro-3-pyridine-5-fluoro-3-pyridine-5-fluoro-3-pyridine-5-fluoro-3-fluoro-5-pyridine-5-fluoro-3-fluoropyridine-5-3-fluoro-3-fluoropyridine-5-fluoro-5-fluoropyridine-3-5-fluoropyridine-5-x-3-fluoro-5-pyridine is called as follows X-ray diffraction cathode (XRPD) cathode (XRPD) cathode of X-ray cathode diffraction (XRPD) cathode (XRPD) cathode cathode (XRPD) cathode cathode cathode of X-ray cathode diffraction (XRPD) cathode (XRPD) cathode, XRPD (XRPD) cathode (XRPD) cathode (XRPD) cathode (XRPD) cathode (XRPD) cathode cathode (XRPD) cathode cathode (XRPD) of X-ray cathode diffraction cathode (XRPD) cathode (XRPD) cathode, XRPD (XRPD) is X-ray cathode diffraction cathode (XRPD) cathode (XRPD) cathode of X-ray cathode diffraction cathode (XRPD) cathode. The peak value is as follows: 12.1 ± 0.1, 0 ± 0 ± 0.0, 0 ± 0.0, 0 ± 0.1, 1, 1, 1, 1, 12.1 ± 0.1 ± 0.1, 1, 2, 2, 1, 1, 2, 1, 2, 2, 2, 2, 2-theta,20.3±0.1±2-theta。 Type A is made of ethanol and tetrahydrofuran (THF),Form B is obtained, inter Alia, from water, ethyl acetate and other sources. These crystalline forms are used to produce drugs to treat or prevent diseases associated with androgenico receptors.Se refiere a procesos para la preparacion de formas cristalinas de 4-[7-(6-ciano-5-trifluorometilpiridin-3-il)-8-oxo-6-tioxo-5,7-diazaespiro[3,4]oct-5-il]-2-fluoro-N-metilbenzamida, denominada Forma A y otra denominada Forma B, en donde la forma A se caracterizada por un patron de difraccion de rayos X en polvo(XRPD) que tiene los siguientes picos 4,8±0,1° 2-theta, 7,1±0,1° 2-theta, 14,2±0,1° 2-theta, 16,3±0,1° 2-theta, 20,1±0,1° 2-theta, y en donde la Forma B se caracterizada por un patron de difraccion de rayos X en polvo(XRPD) que tiene los siguientes picos 12,1±0,1° 2-theta, 16,0±0,1° 2-theta, 16,7±0,1° 2-theta, 20,1±0,1° 2-theta, 20,3±0,1° 2-theta. La Forma A se obtiene a partir del etanol, tetrahidrofurano (THF), entre otros y
