Bernard T. Golding,Richard Franklin,Robert G. Tyson
申请号：
BR112012001551
公开号：
BR112012001551A2
申请日:
2010.07.23
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
Prodrugs of galantamine or its 3-hydroxy metabolite with amino acids or short peptides, pharmaceutical compositions containing such prodrugs and methods for treating a memory or cognition disorder with the galantamine prodrugs are provided herein. Prodrugs having side chains of valine, phenylalanine, tyrosine or para amino benzoic acid and mono-, di- and tripeptides thereof are preferred. Additionally, methods for avoiding or minimizing the adverse gastrointestinal side effects associated with galantamine administration, as well as improving the pharmacokinetics of galantamine are provided herein.
