Jakub Tolar,Bruce Robert Blazar,Daniel Francis Voytas,Mark John Osborn
申请号：
US15311685
公开号：
US20170175143A1
申请日:
2015.05.20
申请国别(地区):
US
年份:
2017
代理人:
摘要：
This disclosure describes methods, polynucleotides, cells, compositions, and treatment methods that involve channeling a genomic nucleotide sequence. Generally, the method includes introducing a donor polynucleotide and a nucleotide that encodes an enzyme that cuts at least one strand of DNA into a cell that has a genomic sequence in need of editing, allowing the enzyme to cut at least one strand of the genomic sequence, and allowing the donor sequence to replace the genomic sequence in need of editing.
