The invention is directed to a composition, a use of the composition and a method of treating addiction to drugs of abuse in a subject, wherein the composition comprises a cabamoyl compound, or pharmaceutically acceptable salt or ester thereof as an active ingredient, and the method comprises administering a therapeutically effective amount of a cabamoyl compound, or pharmaceutically acceptable salt or ester thereof.本發明係關於一種組成物;該組成物之用途;及治療個體對濫用之藥物成癮之方法,其中該組成物包含胺甲醯基化合物或其醫藥學上可接受之鹽或酯作為活性成分,且該方法包含投予治療有效量之胺甲醯基化合物或其醫藥學上可接受之鹽或酯。