INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY
发明人:
KHANG, Dong Woo,강동우,KANG, Sang Soo,강상수,CHOI, Jungil,최정일,NAM, Tae Hyun,남태현
申请号：
KRKR2013/007596
公开号：
WO2014/030975A1
申请日:
2013.08.23
申请国别(地区):
WO
年份:
2014
代理人:
摘要：
The present invention provides a method for manufacturing a carbon nanotube-based anti-cancer agent and an anti-cancer agent manufactured thereby. The method comprises the steps of: (a) transforming the surface of multi-wall nanotubes into a carboxyl group (b) bonding an EDC (N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride) linker to the carboxylized multi-wall carbon nanotubes in pH 5.2-5.5 and (c) bonding the multi-wall carbon nanotubes to which the EDC linker is bonded with the anti-cancer agent in pH 5.9-6.2, thereby providing the anti-cancer agent that can overcome cancer drug resistance.La présente invention concerne un procédé de production dun agent anticancéreux à base de nanotubes de carbone et un agent anticancéreux produit au moyen dudit procédé. Le procédé comprend les étapes consistant à: (a) transformer la surface de nanotubes à parois multiples en un groupe carboxyle b) attacher un élément de liaison EDC (N- (3-Diméthylaminopropyl)-N-éthylcarboiimide hydrochlorure)) aux nanotubes de carbone à parois multiples carboxylés dans des conditions de pH 5,2-5,5 et (c) lier les nanotubes de carbone à multiples parois auxquels est attaché lélément de liaison EDC, à lagent anticancéreux dans des conditions de pH de 5,9 à 6,2, ce qui permet dobtenir lagent anticancéreux qui peut vaincre la résistance aux médicaments anticancéreux.본 발명은 암 내성을 극복할 수 있는 항암제를 제공하기 위하여, (a) 다중벽 탄소나노튜브의 표면을 카복실기로 개질시키는 단계 (b) 상기 카복실화된 다중벽 탄소나노튜브를 pH 5.2~5.5의 조건에서 EDC(N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride) 링커를 결합하는 단계 및 (c) 상기 EDC 링커가 결합된 다중벽 탄소나노튜브를 pH 5.9~6.2의 조건에서 항암제와 결합시키는 단계를 포함하는, 탄소나노튜브 기반의 항암제의 제조방법 및 이를 이용하여 제조된 항암제를 제공한다.
