ALFRED E. TIEFENBACHER (GMBH & CO. KG);NAONOPHARM LTD.
发明人:
申请号：
PT15197874
公开号：
PT3175842T
申请日:
2015.12.03
申请国别(地区):
PT
年份:
2020
代理人:
摘要：
The present invention relates to a simple, robust and effective process for preparing a dry powder inhalation formulation containing at least one drug, preferably a highly active drug, more preferably Tiotropium bromide or Tiotropium bromide monohydrate, and a lactose carrier. The process is characterized in that a three-layered composition containing a drug layer in between layers of the lactose carrier is mixed and the obtained preblend is mixed with additional lactose carrier. The process combines a simple manufacturing procedure with an excellent content uniformity obtained over a wide range of mixing parameters.
