The Board of Trustees of the Leland Stanford Junior University
发明人:
James Y. Chen,Masanori Miyanishi,Irving L. Weissman
申请号：
US15616632
公开号：
US10386361B2
申请日:
2017.06.07
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Hoxb5 identifies long-term hematopoietic stem cells. Expression of Hoxb5 distinguishes between LT-HSCs and non-LT-HSCs, and the marker identifies substantially all LT-HSC in the bone marrow. By utilizing fluorescent proteins under the endogenous expression control of Hoxb5, LT-HSC can be monitored and isolated, including without limitation detection and monitoring of HSC in bone morrow； production of LT-HSC from pluripotent stem cells such as iPS cells； for analysis of early stage LT-HSC； in screening methods for expansion and manipulation of LT-HSC, and the like.
