Compounds derived from N - (1H - indazol - 4-yl) imidazo [1,2-a] pyridin - 3 - carboxamide, inhibitors of the type III receptor tyrosine kinase; Preparation Process; Pharmaceutical Composition and use in the treatment of inflammatory diseases, cardiovascular, autoimmune disorders, fibrosis, pain Burns.
QIAN ZHAO,MARK LAURENCE BOYS,ROBERT KIRK DELISLE,ERIK JAMES HICKEN,APRIL L. KENNEDY,DAVID A. MARESKA,FREDRIK P. MARMSATER,MARK C. MUNSON,BRAD NEWHOUSE,BRYSON RAST,JAMES P. RIZZI,MARTHA E. RODRIGUEZ,GE
申请号:
CL2013001712
公开号:
CL2013001712A1
申请日:
2013.06.13
申请国别(地区):
CL
年份:
2013
代理人:
摘要:
Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.<;p>;SE DESCRIBEN COMPUESTOS DE LA FÓ;RMULA 1: Y SALES FARMACÉ;UTICAMENTE ACEPTABLES DEL MISMO, EN DONDE EN DONDE R 1 , R2 , R 3 , R. R5 Y R6 TIENEN LOS SIGNIFICADOS DADOS EN LA MEMORIA DESCRIPTIVA, SON INHIBIDORES DE CFMS; Y SON Ú;TILES EN EL TRATAMIENTO DE FIBROSIS, ENFERMEDADES RELACIONADAS CON LOS HUESOS, CÁ;NCER, TRASTORNOS AUTOINMUNES, ENFERMEDADES INFLAMATORIAS, ENFERMEDADES CARDIOVASCULARES, DOLOR Y QUEMADURAS EN UN MAMIFERO SE DESCRIBEN ADEMÁ;S SUS COMPOSICIONES FARMACÉ;UTICAS Y SUS PROCEDIMI.TÇ;S DE PREPARACIÓ;N.<;/p>;