The present invention relates to at least one boronic acid compound, at least one stabilizer for said at least one boronic acid compound, and / or said at least one boronic acid compound and said at least one stabilization. Nanoparticles comprising a reaction product of the agent and having a particle size of about 10 to about 1000 nm are provided. The present invention also provides pharmaceutical compositions comprising these nanoparticles and methods for preparing these nanoparticles and pharmaceutical compositions. The present invention also provides nanoparticles and pharmaceutical compositions for the treatment of multiple diseases, particularly multiple myeloma, preferably by parenteral administration.本発明は、少なくとも１種のボロン酸化合物、前記少なくとも１種のボロン酸化合物のための少なくとも１種の安定化剤、および／または前記少なくとも１種のボロン酸化合物と前記少なくとも１種の安定化剤の反応生成物を含み、約１０～約１０００ｎｍの粒径を有するナノ粒子を提供する。本発明はまた、これらナノ粒子を含む医薬品組成物、ならびにこれらナノ粒子および医薬品組成物を調製する方法を提供する。また、本発明は、好ましくは非経口投与により、複数の疾患、特に多発性骨髄腫の治療を行うためのナノ粒子および医薬品組成物を提供する。
