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Compositions and methods for administration to tumors of high oxygen affinity binding agents
专利权人:
Poseida Therapeutics; Inc.
发明人:
GHOROGHCHIAN, P. Peter
申请号:
ES12732165
公开号:
ES2718308T3
申请日:
2012.01.09
申请国别(地区):
ES
年份:
2019
代理人:
摘要:
While tumor hypoxia is recognized as a key barrier to effective chemo and radiation therapy of solid tumor malignancies, and an important biological mediator of more aggressive tumor phenotype and behavior for over 50 years, prior attempts to improve tumor oxygenation have relied on increasing the total amount of oxygen bound to each molecule of natural hemoglobin (e.g. through hyperbaric oxygen treatments), increasing the ease of release of oxygen from hemoglobin (through the introduction of exogenous allosteric small molecules), or increasing the total amount of oxygen in the body by injecting perfluorocarbon emulsions, or polymerized or pegylated compositions of natural human or bovine hemoglobin. The embodiments provide a novel approach of introducing into the vascular system agents that possess inherently higher-affinities for molecular oxygen that that of natural human hemoglobin, and coupling these agents with inert carriers that shield them from unwanted biological interactions within the body.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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