CHO Joung Lag,ЧО Йоунг Лаг,BAEK Sung Joon,БАЕК Сунг Йоон,CHAE Sang Eun,ЧАЕ Санг Еун,KIM Sun Yang,КИМ Сун Янг,LI Khong Bum,ЛИ Хонг Бум,LI Khiang Sook,ЛИ Хианг Соок,OKH Kiuman,ОХ Киуман,KHEO Khie Dzin,Х
申请号：
RU2013143800
公开号：
RU0002617408C2
申请日:
2012.03.29
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to oxazolidinone derivative represented by the formula (1):wherein R is a heterocyclic group selected from the following groups represented by the formula (1a):(1а),R1 is hydrogen, C1-C6-alkyl orC3-C6-cycloalkyl R2 is hydrogen, C1-C6-alkyl, -CH2-CH =CH2, -CH2-FROMCH,≡ -C(O)CH(OH)CH2OH, -CH2-C(O)OC2H5, -CH2CH2OH,-CH2C(O)OH, -CH2C(O)OC(CH3)3, -C(O)CH2OH, -C(O)CH2OC (O)CH3, or (CH2)mC(=O)R21, whereR21 is hydrogen, (CH2)nNHR211, whereR211 is hydrogen or C1-C6 alkyl, or CH(OH)CH2OH, and m and n, each independently represent an integer from 0 to 3 and Q isOR3, NHR3 or 1,2,3-triazole, where R3 is hydrogen, C1-C6-alkyl, -C(=O)R31 or a heteroaromatic cyclic group selected from isoxazol-3-yl orisoxazol-5-yl,R31 is hydrogen, C1-C6-alkyl,C3-C6-cycloalkyl or O-(C1-C6) alkyl. The invention also relates to oxazolidinone prodrug represented by a compound selected from compounds of formulas (5)-(7) wherein Q is the same substituents as specified for the compounds of formula (1), and M+ represents an alkali metal ion such as Na or K Or an ammonium ion. Compounds of the invention also relate to specific oxazolidinone derivatives listed in the claims. Compounds of the invention are intended for manufacture of a pharmaceutical composition for antibiotic comprising (a) a therapeutically effective amount of oxazolidinone and (b) a pharmaceutically acceptable carrier, diluent, excipient or combination thereof.EFFECT: oxazolidinone derivatives with antibiotic activity.6 cl, 1 tbl, 113 ex, ,Изобретение относится к производному оксазолидинона, представленному формулой (1), где R означает гетероциклическую группу, выбираемую из следующих групп, представленных формулой (1а), R1 означает водород, C1-С6-алкил или С3-С6-циклоалкил R2 означает водород, C1-С6-алкил, -СН2-СН=СН2, -СН2-С≡СН, -С(O)СН(ОН)СН2ОН, -СН2-С(О)ОС2Н5, -СН2СН2ОН, -СН2С(O)ОН, -СН2С(O)ОС(СН3)3, -С(O)СН2ОН, -С(O)СН2ОС(O)СН3, или (СН2)mC(=O)R21, где R21 означает водород, (СН2)nNHR211, гд
