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METHODS AND COMPOSITIONS FOR THE TREATMENT OF PERSISTENT INFECTIONS AND CANCER BY INHIBITING THE PROGRAMMED CELL DEATH 1 (PD-1) PATHWAY
专利权人:
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;DANA-FARBER CANCER INSTITUTE;EMORY UNIVERSITY;PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人:
FREEMAN, GORDON,SHARPE, ARLENE,DORFMAN, DAVID M
申请号:
NZ59338806
公开号:
NZ593388A
申请日:
2006.06.08
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
A method of assessing effectiveness of a cancer treatment in a subject administered a PD-L1 antagonist, said method comprising: measuring PD-I expression on T cells in a biological sample from the subject ex vivo, wherein a decrease in PD-I expression on the T cells indicates that the PD-L1 antagonist is efficacious for treating cancer.
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