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Rocuronium formulation with improved stability
专利权人:
Ltd.;Maruishi Pharmaceutical Co.
发明人:
Itsuji, Yutaka,Nagahara, Hironori,Jinbo, Keisuke
申请号:
AU2014398349
公开号:
AU2014398349A1
申请日:
2014.06.26
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
The present invention provides a rocuronium formulation having excellent stability. This formulation includes rocuronium and a buffer solution, and has a pH adjusted to 3.5 or less (for example, 2.5-3.5). The buffer solution may be a citric acid/sodium hydroxide buffer solution, a tartaric acid/sodium hydroxide buffer solution, a potassium hydrogen phthalate/hydrochloric acid buffer solution, a glycine/hydrochloric acid buffer solution or the like. This type of rocuronium formulation has a rocuronium analog C generation rate of 5% or less after being stored for six months at 40 °C, for example.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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