用於腫瘤疫苗接種及免疫療法之涉及HER2／NEU之組合物及方法农业专利-农业学术服务平台

发明人:: JONES, FRANK R.,琼斯　法兰克Ｒ,瓊斯　法蘭克Ｒ,BALINT, JOSEPH,布兰特　约瑟夫,布蘭特　約瑟夫,GODFREY, WAYNE,高佛瑞　韦恩,高佛瑞　韋恩,GABITSCH, ELIZABETH,盖比许　伊莉莎白,蓋比許　伊莉莎白,琼斯法兰克R,瓊斯法蘭克R,布兰特约瑟夫,布蘭特約瑟夫,高佛瑞韦恩,高佛瑞韋恩,盖比许伊莉莎白,蓋比許伊莉莎白

摘要：: In certain embodiments, methods and compositions are provided for generating immune responses against tumor antigens such as a HER2/neu antigen or epitope. In particular embodiments there may be provided methods for constructing and producing recombinant adenovirus-based vector vaccines containing nucleic acid sequences encoding tumor antigens such as a HER2/neu antigen or epitope that allow for vaccinations in individuals with preexisting immunity to adenovirus.在某些實施例中，提供產生針對腫瘤抗原(諸如HER2/neu抗原或抗原決定基)之免疫反應的方法及組合物。在特定實施例中，可提供構築及產生基於腺病毒之重組載體疫苗之方法，該等疫苗含有編碼腫瘤抗原(諸如HER2/neu抗原或抗原決定基)之核酸序列，允許在具有預先存在腺病毒免疫性的個體中接種疫苗。