The present invention relates to a skin administration system capable of improving the efficiency of skin delivery of an ingredient for controlling release of neurotransmitters and, particularly, to a microneedle containing an ingredient for controlling release of neurotransmitters.本發明涉及一種透皮給藥系統,根據該系統,能夠提高調節神經遞質釋放的成分的皮膚透過率,特別地,本發明涉及一種包含調節神經遞質釋放的成分的微針。