AKIHIRO HASHIMOTO,AVINASH PHADKE,JASON ALLAN WILES,MILIND DESHPANDE
申请号：
BR112015025766
公开号：
BR112015025766A2
申请日:
2014.04.14
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract: highly active nucleoside derivative for the treatment of hcv a deuterated nucleoside analog of the formula and the pharmaceutically acceptable salts thereof are provided by this disclosure. the disclosure also includes pharmaceutical compositions comprising a compound or salt of the formula and a carrier. compounds and salts of this formula are useful for treating viral infections, including hcv infections. a method for treating a host afflicted with hepatitis or other disorders is also presented which includes administering an effective treatment of a nucleoside or nucleotide that has deuterium with at least 50% enrichment at the 5'-position of the nucleoside or nucleotide. _________________________________________________________________________________ patent summary: "highly active nucleoside derivative for the treatment of hcv". a deuterated nucleoside analog of the formula and pharmaceutically acceptable salts thereof are provided by this disclosure. The disclosure also includes pharmaceutical compositions comprising a compound or salt of the formula and a carrier. The compounds and salts of the formula are useful for treating viral infections, including hcv infections. A method for treating a host afflicted with hepatitis C or other disorders is also disclosed which includes administering an effective amount of treatment of a nucleoside or nucleotide having deuterium with at least 50% enrichment at the 5 'position of the nucleoside or nucleotide.abstract: highly active nucleoside derivative for the treatment of hcv a deuterated nucleoside analog of the formula and the pharmaceutically acceptable salts thereof are provided by this disclosure. the disclosure also includes pharmaceutical compositions comprising a compound or salt of the formula and a carrier. compounds and salts of this formula are useful for treating viral infections, including hcv infections. a method for treating a host afflicted with hepatitis c or other disorders is also presented
