#$%^&*AU2012254920A120121206.pdf#####C:\NRPortblDCC\SZP741329_ .DOC-1311/2012 ABSTRACT Disclosed is polynucleotide encoding a polypeptide comprising an antibody binding site, the polypeptide being able to bind to HCV E2 samples representative of each of HCV 5 genotypes 1-6, as well as polypeptides having such properties and uses of such polypeptides in detecting and treating HCV infection.