#$%^&*AU2013200041B220161103.pdf#####Abstract A quinazoline derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof: [Chemical 1] RN R 6 HN R3 RN R N NR 0 [1] wherein RI represents hydrogen or alkyl R2 represents hydrogen, alkoxy, tetrahydropyranyl, phenyl, cycloalkyl, (cycloalkyl)alkyl or alkyl, in which the alkoxy, tetrahydropyranyl, phenyl, cycloalkyl, (cycloalkyl)alkyl and alkyl may be substituted with one to three groups selected from the group consisting of (1) alkoxy, (2) halogen, (3) alkoxyalkyl, (4) hydroxy, (5) alkylthio, (6) a 5- to 10-membered aromatic heterocyclic group containing one to three heteroatoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, (7) a 5- to 7-membered saturated aliphatic heterocyclic group which may be substituted with acyl and contains one to three nitrogen atoms, and (8) phenyl which may be substituted with halogen or alkoxy R3 and R4 are the same or different and each represents hydrogen, alkyl, alkoxy or halogen R5 is combined with R6 to represent alkylene, or represents hydrogen, hydroxy, alkyl, phenyl or alkoxy, in which the alkylene may be substituted with hydroxy or oxo, and may be condensed with a benzene ring the alkyl, phenyl and alkoxy represented by R5 may be substituted with one to three groups selected from the group consisting of alkoxy, alkylthio and halogen and R represents (1) alkyl, (2) cycloalkyl, (3) phenyl, (4) a 5- to 10-membered aromatic heterocyclic group containing one to three heteroatoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, in which the alkyl, cycloalkyl, phenyl and aromatic heterocyclic group may be substituted with one to three groups selected from the group consisting of (1) alkoxy, (2) hydroxy, (3) phenyl, (4) pyridyl, (5) furyl, (6) halogen and (7) N,N-dialkylamino. 04/01/13,gfdksipchx,2
