PEGYLATED INSULIN LISPRO COMPOUNDS

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专利权人:

ELI LILLY AND COMPANY

发明人:

BEALS, JOHN, MICHAEL,CUTLER, GORDON, BUTLER,DOYLE, BRANDON,HANSEN, RYAN, JOHN,LI, SHUN,SHIRANI, SHAHRIAR,ZHANG, LIANSHAN

申请号：

NZ58899709

公开号：

NZ588997A

申请日:

2009.06.09

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

A PEGylated (polyethylene glycolated) insulin lispro compound of the formula: P-[(a)-(B)], wherein: A is the A-chain of insulin lispro (SEQ ID NO: 1) B is the B-chain of insulin lispro (SEQ ID NO: 3) and P is a PEG having a molecular weight in the range from about 17.5 kDa to about 40 kDa. A and B are cross-linked and P is attached via a urethane covalent bond to the epsilon-amino group of the lysine at position 28 of B. The compound can be used to treat hyperglycaemia or diabetes.

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