Chromosome Engineering: Technologies, Applications, and Challenges

• 全文链接

染色体工程：技术、应用和挑战

关键词：

来源：

Annu Rev Anim Biosci

全文链接：

//agri.nais.net.cn/topic/downloadFile/fe0b9226-23b9-436f-96f4-58d2e7f501e5

来源地址：

https://pubmed.ncbi.nlm.nih.gov/39541223/

资源所属：

马铃薯基因组设计育种

类型：

学术文献

语种：

英语

原文发布日期：

2024-11-14

摘要：

Chromosome engineering is a transformative field at the cutting edge of biological science, offering unprecedented precision in manipulating large-scale genomic DNA within cells. This discipline is central to deciphering how the multifaceted roles of chromosomes-guarding genetic information, encoding sequence positional information, and influencing organismal traits-shape the genetic blueprint of life. This review comprehensively examines the technological advancements in chromosome engineering, which center on engineering chromosomal rearrangements, generating artificial chromosomes, de novo synthesizing chromosomes, and transferring chromosomes. Additionally, we introduce the application progress of chromosome engineering in basic and applied research fields, showcasing its capacity to deepen our knowledge of genetics and catalyze breakthroughs in therapeutic strategies. Finally, we conclude with a discussion of the challenges the field faces and highlight the profound implications that chromosome engineering holds for the future of modern biology and medical applications.