The stereoselective bioactivity and mechanism of indoxacarb against Spodoptera frugiperda
茚虫威对草地贪夜蛾的立体选择性生物活性及其作用机制
- 关键词：
- 来源：
- Pest Management Science 期刊
- 类型：
- 学术文献
- 语种：
- 英语
- 原文发布日期：
- 2025-01-09
- 摘要：
- BACKGROUND：Indoxacarb, a type of chiral pesticide, is used tocontrol Lepidoptera insects. Most studies had focused on theenvironmental behavior and selective toxicity of indoxacarb enantiomers, andthe mechanism behind its selective biological activity against target organismsis not well understood.RESULTS：Spodoptera frugiperda was selected as the target insect. The lethalconcentrations (96 h) of indoxacarb enantiomerson S. frugiperda were 2.61 mg/kg (S-indoxacarb) and 463.52 mg/kg (R-indoxacarb). S-Indoxacarbresulted in stronger oxidative damage to S. frugiperda than R-indoxacarb,and catalase and malondialdehyde were upregulated by 40.46% and 68.64%respectively after treatment with S-indoxacarb. Furthermore,cytochrome P450 and carboxylesterase were activated by S-indoxacarb,increasing by 39.62% and 63.68% respectively. Decarbomethoxyllated JW062(DCJW), a metabolite of indoxacarb, has insecticidal activity. Theconcentration of DCJW in the S-indoxacarb treatment group was 2.73times that in the R-indoxacarb treatment group. Molecular dockingresults demonstrated that S-indoxacarb could spontaneously bind tometabolic enzymes and be metabolized.CONCLUSIONS：Enantiomeric bioactivity ofindoxacarb enantiomers against on S. frugiperda wasobserved. S-Indoxacarb demonstrated remarkable insecticidalefficacy. Upon ingestion by S. frugiperda, it induced oxidativedamage. Furthermore, S-indoxacarb was metabolized to DCJW, whichhas a significant role in its insecticidal properties. The selectivebioactivity of indoxacarb enantiomers in S. frugiperda mightbe attributed to the enantiomeric metabolites. These findings offer a newperspective on the selective mechanisms of chiral pesticides. © 2025 Society ofChemical Industry.
- 所属专题：
- 60
