Context-aware geometric deep learning for protein sequence design

• 全文链接

基于上下文感知几何深度学习的蛋白质序列设计

关键词：

来源：

Nature Communications

全文链接：

//agri.nais.net.cn/topic/downloadFile/ab3dac77-d61d-4a07-98f3-b842d5138b47

来源地址：

https://www.nature.com/articles/s41467-024-50571-y

资源所属：

饲料用酶工程

类型：

学术文献

语种：

英语

原文发布日期：

2024-07-25

摘要：

Protein design and engineering are evolving at an unprecedented pace leveraging the advances in deep learning. Current models nonetheless cannot natively consider non-protein entities within the design process. Here, we introduce a deep learning approach based solely on a geometric transformer of atomic coordinates and element names that predicts protein sequences from backbone scaffolds aware of the restraints imposed by diverse molecular environments. To validate the method, we show that it can produce highly thermostable, catalytically active enzymes with high success rates. This concept is anticipated to improve the versatility of protein design pipelines for crafting desired functions.Advances in deep learning are transforming protein design. Here, authors introduce a method using geometric transformers to predict protein sequences, resulting in highly thermostable and catalytically active enzymes with high success rates.