A cellulose synthase–like protein governs the biosynthesis of Solanum alkaloids

• 全文链接

一种类似纤维素合成酶的蛋白质控制着茄碱的生物合成

关键词：

来源：

SCIENCE / PLANT SCIENCE

全文链接：

//agri.nais.net.cn/topic/downloadFile/a3473ae8-2fb0-4efb-a156-f0e4208464ab

来源地址：

https://www.science.org/doi/10.1126/science.adq5721

资源所属：

马铃薯基因组设计育种

类型：

学术文献

语种：

英语

原文发布日期：

2024-12-20

摘要：

Steroid-based natural products produced in Solanum species act as chemical defense molecules against pests and pathogens, and some also have antinutritional properties for humans. Two groups now report the identification of a cellulose synthase–like protein named GAME15 that directs the biosynthesis of these secondary metabolites. Jozwiak et al. found that GAME15 functions both as a cholesterol glucuronosyltransferase and as a scaffolding protein in a metabolon that controls cholesterol and steroidal glycoalkaloid intermediates. Boccia et al. identified the same protein and showed that deletion of the corresponding gene in Solanum nigrum produced plants lacking both steroidal alkaloids and saponins. Identification of GAME15 will pave the way to engineering the production of chemical defense molecules in heterologous plant hosts, and may aid our understanding of the balance between chemical defense and self-toxicity.