Asimov Launches Stable AAV Producer Cell Lines, Setting a New Standard for Viral Vector Manufacturing

阿西莫夫推出稳定的AAV生产细胞系，为病毒载体生产树立新标准

关键词：

来源：

Asimov 公司

来源地址：

https://www.asimov.com/news/asimov-launches-stable-aav-producer-cell-lines-setting-a-new-standard-for-viral-vector-manufacturing

资源所属：

马铃薯基因组设计育种

类型：

前沿资讯

语种：

英语

原文发布日期：

2025-10-06

摘要：

"Asimov’s AAV Edge Stable Producer System brings AAV manufacturing in line with the gold-standard practices long established in protein biologics. By stably integrating all essential viral genes into the genome of HEK293 cells, Asimov generates high-titer, clonal producer cell lines. Stable clones eliminate the need for costly GMP plasmids, enable straightforward scale-up in bioreactors, and minimize batch-to-batch variability. The result is lower manufacturing cost, more consistent product quality, and the potential for safer, more effective AAV gene therapies.Asimov’s new offering delivers research cell banks (RCBs) within 20 weeks that contain the desired capsid and transgene. Therapeutic developers receive clonal, suspension-adapted, fully stable AAV HEK293 producer cell lines that enable reliable manufacture of gene therapies at scale, with titers up to 6E15 vg/L before purification."