Natural Compounds as Therapeutic Agents for Amyloidogenic Diseases

• 全文链接

天然化合物作为淀粉样变性疾病的治疗剂

关键词：

来源：

SpringerLink 网站

全文链接：

//agri.nais.net.cn/topic/downloadFile/9b6a50b7-4eb8-4162-81ea-88008d5a68e9

来源地址：

https://link.springer.com/book/10.1007/978-3-319-18365-7

资源所属：

茶学研究专题

类型：

科技图书

语种：

英语

原文发布日期：

2015-06-19

摘要：

This edited volume concerns a group of devastating neurological disorders that share a common pathological mechanism, namely the aggregation and deposition of insoluble, proteinaceous lesions, termed ‘amyloid’. Examples of cerebral amyloid disorders include common neurodegenerative diseases like Alzheimer’s disease-related dementia and Parkinson’s disease, as well as other less prevalent conditions like Huntington’s disease, cerebral amyloid angiopathy and the transmissible prion disorders. A disease-modifying therapeutic agent is still lacking for all these diseases, and there are no approved therapies that target amyloid formation directly. Nevertheless, a large and complex group of natural aromatic compounds known as polyphenols are rapidly emerging as potentially potent anti-amyloidogenic agents. This book collectively presents a considerable body of experimental and epidemiological evidence from peer-reviewed scientific publications that support a role for natural compounds and herbal extracts in the chemoprevention and therapy of amyloidogenic disorders. Each contribution is written by scientific experts in the relevant field; chapters are devoted to Mediterranean diet and olive oil phenols, traditional Chinese medicine, herbal extracts, polyphenols (with a particular emphasis on epigallocatechin-3-gallate) and bi-flavonoids, amongst others.