Neonicotinoid Insecticides and Their Characteristic Metabolites may Induce High Fasting Blood Glucose and Obesity in Human
新烟碱类杀虫剂及其特征代谢产物可能导致人类空腹血糖升高和肥胖
- 关键词：
- 来源：
- Exposure and Health 期刊
- 类型：
- 学术文献
- 语种：
- 英语
- 原文发布日期：
- 2024-03-14
- 摘要：
- In this study, the concentrations of six NEOs and their five metabolites were measured in the blood samples collected from the normal (n = 130) and obesity (n = 130) cohorts in South China. An evaluation was undertaken to examine the associations between the levels of target analytes and either fasting blood glucose (FBG) or the condition of being overweight. Results showed that the NEOs and their metabolites were frequently detected (63–100%) in both cohorts, with median levels of 0.01–4.32 ng/mL. Discernible gender-related disparities were noted within the blood samples, manifesting as elevated concentrations of the majority of NEOs and their metabolites in females compared to males. In addition, there were positive correlations between the concentrations of IMIeq (imidacloprid equivalent, calculated using the relative potency factors of NEOs and their metabolites) and 1-methyl-3-(tetrahydro-3-furylmethyl) urea (UF, a metabolite of dinotefuran) with FBG levels (3.28 ng/mL vs. 4.32 ng/mL for UF, and 34.6 ng/mL vs. 40.6 ng/mL for IMIeq). Moreover, significant associations were found between UF [odds ratio 1.78, 95% confidence interval (CI) 0.86–4.66, p < 0.01] and IMIeq (odds ratio 1.66, 95% CI 0.94–3.56, p < 0.01) concentrations and being overweight. Our findings indicated that human exposure to NEOs and their metabolites may induce high FBG and obesity. This study documented the profile of NEOs and their metabolites in the blood samples from the normal and obesity cohorts in South China for the first time.
- 所属专题：
- 60
