Constructive Bio secures exclusive licence for groundbreaking tRNA display technology

Constructive Bio 获得一项开创性 tRNA 展示技术的独家授权

关键词：

来源：

Constructive Bio公司

来源地址：

https://www.constructive.bio/blog/news/constructive-bio-secures-exclusive-licence-for-groundbreaking-t-rna-display-technology-1

资源所属：

马铃薯基因组设计育种

类型：

前沿资讯

语种：

英语

原文发布日期：

2025-06-04

摘要：

"Constructive Bio, a leader in synthetic biology and genome recoding, today announces it has secured the exclusive licence to groundbreaking ‘tRNA Display’ technology from the MRC Laboratory of Molecular Biology. This technology revolutionises protein engineering by enabling the integration of new-to-nature building blocks (non-canonical amino acids) into peptides and proteins.tRNA Display technology allows the rapid and accurate selection of enzymes (tRNA synthetases) that are critical for the seamless integration of non-canonical amino acids into proteins and peptides. It can be used to discover enzymes capable of incorporating novel monomers, as well as enzymes that significantly enhance manufacturing yields. This allows for the creation of next-generation therapeutics with enhanced properties, at scale and speed.Constructive Bio will deploy this transformative technology to accelerate the development and scalable biomanufacturing of next-generation therapeutics, such as precision-targeted medicines. The commercial potential extends beyond medicine development and discovery, with future applications in agriculture and high-tech materials, offering bio-based alternatives to traditional manufacturing processes."