Advances and prospects in microbial production of biotin

• 全文链接

微生物生产生物素的研究进展与展望

关键词：

来源：

Microbial Cell Factories

全文链接：

//agri.nais.net.cn/topic/downloadFile/4d1be119-e8f5-4eb5-9673-7663b631b03f

来源地址：

https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-024-02413-1

资源所属：

饲料用酶工程

类型：

学术文献

语种：

英语

原文发布日期：

2024-05-12

摘要：

Biotin, serving as a coenzyme in carboxylation reactions, is a vital nutrient crucial for the natural growth, development, and overall well-being of both humans and animals. Consequently, biotin is widely utilized in various industries, including feed, food, and pharmaceuticals. Despite its potential advantages, the chemical synthesis of biotin for commercial production encounters environmental and safety challenges. The burgeoning field of synthetic biology now allows for the creation of microbial cell factories producing bio-based products, offering a cost-effective alternative to chemical synthesis for biotin production. This review outlines the pathway and regulatory mechanism involved in biotin biosynthesis. Then, the strategies to enhance biotin production through both traditional chemical mutagenesis and advanced metabolic engineering are discussed. Finally, the article explores the limitations and future prospects of microbial biotin production. This comprehensive review not only discusses strategies for biotin enhancement but also provides in-depth insights into systematic metabolic engineering approaches aimed at boosting biotin production.