Reversal of the histidine kinase activity by a small linker helix

• 全文链接

通过连接螺旋逆转组氨酸激酶活性

关键词：

来源：

Eurekalert

全文链接：

//agri.nais.net.cn/topic/downloadFile/2a2ef283-8244-4a47-96d7-9561cccd8e9b

来源地址：

https://www.eurekalert.org/news-releases/1048259

资源所属：

饲料用酶工程

类型：

前沿资讯

语种：

英语

原文发布日期：

2024-06-14

摘要：

Scientists have revealed new information on how red light-regulated histidine kinases function. According to the study, altering of the length of a specific ‘linker helix’ region of the protein can even reverse their enzymatic activity. The study is published in Nature Communications. An international collaboration between the groups of Dr. Heikki Takala from the University of Jyväskylä and Prof. Andreas Möglich from the University of Bayreuth have revealed key details on histidine kinase signaling. By applying modifications in their pREDusk tool, they showed how the delicate balance between kinase and phosphatase activities is fine-tuned in histidine kinase receptors. Importantly, they also revealed that certain deletions in a so-called ‘linker helix’ of the phytochrome component reverses their enzymatic activity.