Role of the HIF oxygen sensing pathway in cell defense and proliferation through the control of amino acid metabolism

• 全文链接

HIF氧敏感通路在调控氨基酸代谢的细胞防御和增殖中的作用

关键词：

来源：

中国知网

全文链接：

//agri.nais.net.cn/topic/downloadFile/15928baf-28da-4f25-80bb-6a0139dac958

来源地址：

https://www.sciencedirect.com/science/article/pii/S0167488920300914

资源所属：

动物营养专题

类型：

学术文献

语种：

英语

原文发布日期：

2020-06-15

摘要：

Cell responses to reduced oxygen supply (hypoxia) are largely mediated by hypoxia-inducible transcription factors (HIFs). The pathophysiological role of the HIF pathway is driven by its ability to potentiate key biological processes as part of the adaptation to hypoxia, such as erythropoiesis and angiogenesis. Moreover, the role of HIF signaling in the reprogramming of cell metabolism is also critical to understand the role of these transcription factors in health and disease. In this regard, HIFs reprogram oxidative metabolism of glucose and fatty acids, offering a molecular mechanism by which the HIF pathway can help cells become more tolerant of redox stress during hypoxic/ischemic episodes. However, the way in which HIFs influence amino acid metabolism and its pathophysiology consequences have been less well explored. Here we review recent studies about the role of the HIF1α and HIF2α isoforms in amino acid metabolism, which provides insight to better understand how these factors can influence cell autonomous proliferation and cellular tolerance to hypoxia.